Hormones Peptide Grf 1-29/Sermorelin for Bodybuilding
Product Name:Sermorelin Acetate,GRF 1-29
Sermorelin Alias:Somatoliberin,Sermorelin ,Sermorelinum,Sermorelina,Sermoreline
Sermorelin CAS No.: 86168-78-7
Sermorelin Molecular Formula: C149H246N44O42S
Sermorelin Molecular Weight: 3357.96
Sermorelin Purity (HPLC): 98.0%min.
Sermorelin Appearance: White powder
Sermorelin Grade:Pharmaceutical Grade
Sermorelin acetate is a recently synthesized (man-made) peptide analogue of growth hormone releasing hormone (GHRH) a naturally occurring hormone that is produced in the hypothalamus and stimulates and controls the production of growth hormone (GH) within the pituitary gland. GHRH, which is necessary for growth and development, was first described by Nobel Laureates R. Guilleman and A Shalley. In the 1970s one of their students, William Wehrenberg, began studying which part of the GHRH molecule was essential in stimulating the pituitary gland.
SERMORELIN FUNCTION AND TRAITS
By removing individual amino acids from the GHRH molecule, Wehrenberg found that only the first 29 amino acids were essential for the stimulation of GH production in the pituitary gland. Semorelin is therefore only comprised of these 29 essential amino acids, forming a short polypeptide chain that is considered one of the shortest functional fragments of the GHRH molecule. It was first developed with a one-step chromatographic method capable of separating all isomers of polyethylene glycol (PEG) from naturally occurring GHRH.
The biological effects of sermorelin were first observed in vitro cultures of rat pituitary cells. When compared to other GHRH analogues, sermorelin was found to be the most potent, potentially 4-5 times as potent as naturally produced GHRH. Recent studies of other GHRH analogues in pigs have also found synthetic GHRH analogues to be more effective than the naturally occurring hormone.
Sermorelin is now used as a standard test for growth hormone secretion and is primarily prescribed for children who do not produce GH properly and fail to grow healthily as a result. It has a secondary, off-label use in “repairing” declining GH levels (a natural side effect of aging that leads to weight gain, decreased strength and muscle mass, and insomnia in elder subjects). GH levels typically peak at around 20 years of age in humans and fall by about 14% for every decade that passes, but use of Sermorelin can potentially rejuvenate GH back to youthful levels.
EFFECTS OF SEMORELIN
Sermorelin has a wide range of positive effects. Due to its nature as a GHRH, sermorelin only increases the body’s ability to produce more growth hormone; it is not an injection of growth hormone itself. In both a performance enhancing and general well-being sense, sermorelin has a wide array of benefits that make it a powerful and valuable substance.
Mental: Focus and mental clarity improve, leading to an easing of general day-to-day tasks. Libido can be heightened and users have reported an improvement in their sex lives. General fatigue as well depression can also be reduced. All of these qualities can lead to a generally healthier, happier lifestyle.
Physical: Sermorelin increases the development of lean body mass through the development of new muscle cells and reduces body fat through lipolysis. This leads to increased strength and endurance and improved muscle tone as well as improved skin elasticity (smoother, less wrinkly skin) and loss of cellulite. Calcium retention improves, leading to the increased mineralization of bone (bone density), strengthening the skeletal system.
General enhancement: Protein synthesis increases, leading to the stimulation of all internal organs (including the heart) except for the brain. Cholesterol levels fall. Regardless of the purpose of use, joint and muscle pain is lessened, one’s recovery time from wounds increases, and the immune system improves. The individual will not tire as quickly and will be able to go longer in their daily activities, be those exercise related or other. Deeper, more restful and satisfying sleep can be expected (some have reported more vivid dreams) and hair can becomes thicker, fuller, and more lustrous.
Sermorelin is prescribed as a fine white powder of a variable dose (in milligrams) in a vial that must be mixed with bacteriostatic water or medical grade saline solution as a diluent. The powder should be stored out of light at or below room temperature. The solution is used by injection into subcutaneous (below the skin) body fat using a very small needle, comparable to what a diabetic would use to take their insulin shots.
Once combined into solution form, sermorelin must be kept in the refrigerator (do not freeze-store between 2 and 8°C/36 and 46°F) ) and out of light or else the chain of amino acids will break down and it will be rendered ineffective. Before use, check the liquid for particles or discoloration and, if found, discard the solution. As with most peptides, there is a saturation dose at which point taking any more of the peptide will not increase the production of growth hormone, a consequence of the body’s natural mechanism to keep hormonal levels at a safe homeostasis. This saturation dose is typically around 100mcg.
It is best to use a different place on the body for each injection (for example, abdomen, hip, thigh, or upper arm). The dose of this medicine will be different for different patients based off of their body-mass index (BMI); use it exactly as directed by your doctor and do not use it more often than your doctor prescribed. Sermorelin has an ongoing effect in which optimal HGH levels can be sustained long after the last injection. Just like synthetic GH, sermorelin initially must be injected every day. Unlike synthetic HGH, once optimal levels reached, injection frequency can be decreased or stopped altogether
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