Pain killer Local Anesthetic white powder Lidocaine HCL Steroids

Local Anesthetic Lidocaine
Lidocaine
Lidocaine Basic Information:
Product Name: Lidocaine
Lidocaine CAS: 137-58-6
Lidocaine MF: C14H22N2O
Lidocaine MW: 234.34
Lidocaine EINECS: 205-302-8
Lidocaine mp: 66-69°C
Lidocaine storage temp: Store at RT
Lidocaine solubility ethanol: 4 mg/mL
Lidocaine form: powder
Lidocaine Water Solubility: practically insoluble
Lidocaine Stability: Stable. Incompatible with strong oxidizing agents.
Lidocaine Usage: Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

16_副本

Lidocaine,xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug.

Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or used as a local anesthetic for minor surgery.

Lidocaine Application
Lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.

Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide.

The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged.

Function of Lidocaine
1- For block anesthesia and epidural anesthesia.
2- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
3- As painkillers of injection in the medicament.
4- Also used in suppository and ointment preparation, etc.

Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated.

Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the cough reflex.

This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anesthesia.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

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